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Microsoft Word - Prachayasittikul_novel_activities_proof.doc
dine (6), 2-(1-adamantyl- thio)nicotinic acid (7), 2-(1-adaman- tylthio)nicotinamide(8), 2-(1-adaman- tylthio)nicotinonitrile (9) and 6-(1-adaman- tylthio)nicotinonitrile (10). The compounds 1-6 (Prac [...] 5 and 6 are new types of analogs with anticancer activity.
Table 3: Antimalarial activity of 1-adamantylthiopyridines 1-10
Compound Activity IC50 (M) 1,7,8 inactive >10-5
2,3,4,5,6,9,10 fair 10-6- <10-5 [...] 3-Substituted (R) thiopyridines; 3 (R = NAc2), 5 (R = OH) and 6 (R = Br) exhibited antibacterials, antimalarials and anticancers. Significantly, 6-(1-adamantylthio) nicotinonitrile (10) is a promising ant …