eldorado.tu-dortmund.de/items/4cb8abf0-748a-4a2d-8091-a98d1e740b9b/full
Hepatoprotective effects of citric acid and aspartame on carbon tetrachloride-induced hepatic damage
the CCl4-induced hepatic injury in rats. Citric acid (10 mg/kg, 100 mg/kg or 1000 mg/kg), aspartame (0.625 or 1.25 mg/kg) or silymarin (25 mg/kg) was given once daily orally simultaneously with CCl4 and for [...] for one week thereafter. The administration of citric acid at 100 mg/kg or 1000 mg/kg to CCl4-treated rats reduced elevated plasma ALT by 44.1-63.3 %, AST by 47.8-70.6 %, ALP by 41.7-67.2 %, respectively [...] compared to controls. Aspartame at 0.625 or 1.25 mg/kg reduced plasma ALT by 39.8-52.0 %, AST by 43.2-52.4 % and ALP by 50.0-68.5 %, respectively. Meanwhile, silymarin at 25 mg/kg reduced ALT, AST and ALP levels …
