TABLE OF CONTENTS ABSTRACT I KURZZUSAMMENFASSUNG IV 1. GENERAL INTRODUCTION 9 1.1. Chemical genetics approaches in chemical biology 9 1.2. Phenotypic screening 10 1.3. Target identification 11 1.3.1. Affinity [...] scaffold, namely Autoxain. Autoxain inhibited starvation-induced autophagy with an IC50 of 2.7 ± 1.9 µM. A thermal proteome profiling experiment performed for target identification revealed a high amount [...] üsts, genannt Autoxain. Autoxain inhibiert Hunger-induzierte Autophagie mit einem IC50 von 2.7 ± 1.9 µM. Ein Experiment zur Erstellung des thermischen Proteom Profils (thermal proteome profiling), welches …

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