......................... 9 1.6. Cyclic peptide libraries ......................................................................................................... 9 1.6.1. Genetically encoded libraries [...] folds into a helix (helix 3) upon binding of RBM20 to RNA with a UCUU sequence, see PDB structures 6so9 and 6soe (Figure 17). On the other hand, when the helix is removed the binding affinity of the protein [...] and unbound to RBM20. Shown in beige is the RNA bound RRM domain of RBM20 (PDB: 6so9), in green the unbound RBM20 (PDB: 6soe). Helix 3 is indicated and makes a dramatic conformational shift upon RNA binding …

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Caspase-8 FLICE, MACH1, MCH5, FADD-like Ice Caspase-9 MCH6, ICELAP6 Initiator (or Apical) Caspase-10 FLICE2, MCH4 Caspase-3 CPP32, YAMA Caspase-6 MCH2 Effectors (or executioner) Caspase-7 MCH3, CMH, ICELAP3 [...] damage and production of the predominant lesions such as cyclobutane pyrimidine dimers (CPDs), 6–4 photopro- ducts (6–4PPs) and certain other lesions (Sinha & Häder, 2002; Kumari et al., 2008) as a result of [...] Apoptotic protease activat- ing factor Apaf-1 APAF1 Intrinsic Apoptosis inducing factor AIF Apaf-3/ICE-LAP6/Mch6 Intrinsic B-cell lymphoma protein 2 Bcl-2 Apoptosis regulator Bcl-2 Intrinsic BCL2 like 1 Bcl-x BCL2 …