eldorado.tu-dortmund.de/items/f1024ab8-2fe1-4ebd-a719-6d8b20072056/full
Entwicklung eines in vitro Systems zur Untersuchung von substanzinduzierten Genexpressionsänderungen
group 1: Abcb1, Ugt1a6, Gsta5, Gsta2, Hsf1, Nqo1, Apex1, Bax, Cdkn1a, Gadd45a, Mt1a, Sds, Mdm2, Myc) and one gene group which is active during cell proliferation (gene group 2: Mcm6, Cdc2, Hdc, 3-Pgdh, [...] optimized system, show a deregulation at a level of 0.39 μM and a clear deregulation at a level of 6.25 μM methapyrilene. It is known from the literature, that an i.p.-injection of 0.7 mg/kg BW methapyrilene [...] deposit true de
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