4-Hydroxy-2-nonenal induces endothelial cell injury via PKCdelta and biphasic JNK activation

Publisher Alternative Title(s) Abstract 4-Hydroxy-2-nonenal (4-HNE), a major product generated during oxidative stress, exhibits cytotoxic effects; however, the mechanisms of 4-HNE-induced endothelial cell injury [...] cytotoxic effects of 4-HNE. Inhibition of protein kinase Cd (PKCd), which was also phosphorylated by 4-HNE, reduced endothelial cell injury as well as late-phase JNK phosphorylation elicited by 4-HNE. Inversely [...] Clinical Sciences 2008 - Volume 7 Original Articles 4-Hydroxy-2-nonenal induces endothelial cell injury via PKCdelta and biphasic JNK activation   4-Hydroxy-2-nonenal induces endothelial cell injury via …

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