eldorado.tu-dortmund.de/items/a5d7564d-8661-4233-89a0-95235df12eff
Persons with multiple sclerosis reveal distinct kynurenine pathway metabolite patterns
The healthy control (HC) cohort included 111 participants (53.2% female) with a mean (SD) age of 45.7 (16.6) years. Persons with MS showed 2 distinct KP metabolite patterns: an inflammation-driven neurotoxic [...] cardiorespiratory fitness. Discussion Using a data-driven approach, we demonstrate the presence of 2 KP metabolite patterns, NeuroTox and NeuroPro, in MS. Greater NeuroTox and lower NeuroPro were both …